Some drugs may affect the way tramadol works, and tramadol may affect other drugs you are taking. Let your doctor know about all drugs you are taking, including any illegal, recreational, or. I decided to stop after taking tramadol from back surgery. I was on it for over 6 yrs and I was up to about 18 50mg pills a day. I decided 2 weeks ago to stop and never looked back. TRAMADOL, KETAMINE AND LYRICA (ie Pregabalin). I have been on all of these at times. Tramadol was a very good painkiller for me and I am going back on it for breakthrough pain. Pregabalin appears to have similar efficacy to that of amitriptyline and gabapentin for neuropathic pain Pregabalin is superior in efficacy to placebo and appears to be non-inferior in efficacy and safety to amitriptyline and gabapentin (from indirect comparisons). Lyrica (pregabalin) the drug treatment for neuropathic pain (including diabetic nerve pain), shingles, fibromyalgia, seizures. Side effects are fatigue, blurred or double vision, dry mouth, and dizziness. Dosage, drug interactions, and pregnancy and breastfeeding safety information are provided. I am unable to take morphine (I have a bad reaction to it) so at the mo I'm taking tramadol which isn't touch the pain anymore as I've been taking it for months now. Before starting pregabalin, there are several precautions and warnings to be aware of. For example, combining pregabalin with certain other drugs can potentially lead to drug interactions. If you have become addicted to Lyrica and stop taking it or drastically reduce the dose, it can result in several withdrawal symptoms. In some situations, these symptoms may become life-threatening and even require medical care. Lyrica, or pregabalin, is an anti-seizure drug that can treat a range of conditions, including epilepsy, fibromyalgia, and nerve pain. However, it does lead to some side effects, and there is a. Take the morning dose of immediate-release pregabalin as prescribed and begin extended-release pregabalin after an evening meal. Use the total daily dose of immediate-release pregabalin to convert the patient to an extended-release dose to be given once daily.